Neurobiology of Disease PSD-95 Is Essential for Hallucinogen and Atypical Antipsychotic Drug Actions at Serotonin Receptors
نویسندگان
چکیده
Atheir I. Abbas,1* Prem N. Yadav,2* Wei-Dong Yao,7,8,9,10 Margaret I. Arbuckle,11 Seth G. N. Grant,11,12 Marc G. Caron,7,8,9 and Bryan L. Roth1,2,3,4,5,6 1Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, Departments of 2Pharmacology, 3Medicinal Chemistry, and 4Psychiatry, 5Lineberger Cancer Center, and 6National Institute of Mental Health Psychoactive Drug Screening Program, University of North Carolina, Chapel Hill, North Carolina 27599, Departments of 7Cell Biology, 8Medicine, and 9Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, 10Department of Psychiatry, Division of Neurosciences, New England Primate Research Center, Harvard Medical School, Boston, Massachusetts 02115, 11Division of Neuroscience, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom, and 12Genes to Cognition Programme, Wellcome Trust Sanger Institute, Cambridge CB10 1SA, United Kingdom
منابع مشابه
PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors.
Here, we report that postsynaptic density protein of 95 kDa (PSD-95), a postsynaptic density scaffolding protein, classically conceptualized as being essential for the regulation of ionotropic glutamatergic signaling at the postsynaptic membrane, plays an unanticipated and essential role in mediating the actions of hallucinogens and atypical antipsychotic drugs at 5-HT(2A) and 5-HT(2C) serotone...
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